RAF Typhoon FGR4s have operated alongside France's air force in a joint strike on an hidden munitions depot in Syria operated by the IS group, per a report from the UK Ministry of Defence.
The facility, pinpointed through surveillance, was believed to be containing munitions and bombs, the statement said, and was situated in mountainous terrain just north of Palmyra in Syria's central region.
"Our aircraft used laser-guided Paveway IV weapons to target a number of access tunnels leading to the depot... early reports suggest the strike was effective," officials stated.
There was no evidence of any civilian impact in the strike on Saturday evening and each participating jet returned to base without incident, the MoD added.
The Typhoon FGR4s were backed up by a Voyager aerial refuelling aircraft.
The Islamic State group - also known as Daesh - imposed jihadist rule over parts of both Syria and Iraq until 2019.
"This action underscores the UK's leading role, and determination to stand shoulder to shoulder with our partners, to eliminate any revival of Daesh and their violent and radical beliefs in the area," UK Defence Secretary the Defence Secretary said.
UK warplanes have performed overwatch operations over Syrian airspace to "deter any efforts to regroup" of IS following its defeat at the Baghuz confrontation in 2019, the ministry said.
"I extend gratitude to the personnel of British forces who took part in this mission for their skill and their courage," the Defence Secretary commented. "Including them were numerous British personnel on duty over the festive period. This action, to take out terrorist threats who pose a risk to our safety, shows how UK forces are prepared to act, continuously, protecting the UK domestically and powerful internationally."
Last December, the United States armed forces executed what it called a "major assault" on Daesh sites in Syria, subsequent to an attack killed two American soldiers and a civilian interpreter in Palmyra.
The UN says Daesh still maintains between 5,000 and 7,000 combatants in Syria and Iraq.